Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188232 | 0.89 | MET (1.00) | METMAPK14RAF1DYRK1AMAPK13 | |
| SCHEMBL2286561 | 0.89 | MET (1.00) | METMAPK14RAF1DYRK1AMAPK13 | |
| SCHEMBL2286057 | 0.87 | MET (0.77) | METMAPK14RAF1 | |
| SCHEMBL2293156 | 0.86 | MET (0.74) | METMAPK14RAF1DYRK1AMAPK13 | |
| SCHEMBL12414715 | 0.86 | MET (1.00) | METMAPK14RAF1DYRK1AMAPK13 | |
| SCHEMBL2289909 | 0.85 | MET (0.91) | METMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2186136 | 0.85 | MET (1.00) | METMAPK14RAF1DYRK1AMAPK13 | |
| SCHEMBL2289893 | 0.83 | MET (0.69) | METMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2288612 | 0.82 | MET (0.68) | METMAPK14 | |
| SCHEMBL2286491 | 0.82 | MET (0.70) | METMAPK14RAF1DYRK1AMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | claimed |
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | disclosed |
| WO-2010046013-A1 | AZAINDOLE DERIVATIVE | MERCK PATENT GMBH (DE) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | AZI2, ABL1, RET | MET 8/4885MAPK14 818/4885RAF1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.