Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22415486 | 0.83 | TDP1 (0.36) | TDP1 | |
| SCHEMBL2735586 | 0.83 | TDP1 (0.56) | TDP1ALDH1A1GAA | |
| SCHEMBL8267056 | 0.78 | — | — | |
| SCHEMBL21974896 | 0.76 | ALDH1A1 (0.36) | TDP1ALDH1A1CYP2D6KCNH2CACNA1B | |
| SCHEMBL10606032 | 0.75 | TDP1 (0.47) | TDP1ALDH1A1GAA | |
| SCHEMBL24104595 | 0.74 | ALDH1A1 (0.44) | ALDH1A1CYP2D6KCNH2CACNA1BGAA | |
| SCHEMBL12707168 | 0.73 | TDP1 (0.45) | TDP1ALDH1A1GAA | |
| SCHEMBL14536188 | 0.73 | TDP1 (0.45) | TDP1ALDH1A1CYP2D6 | |
| SCHEMBL14890651 | 0.73 | TDP1 (0.45) | TDP1ALDH1A1GAA | |
| SCHEMBL12035873 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906245-B1 | DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASES OF THE JOINT | ASCENDIS PHARMA AS (DK) | 2021-01-13 | — | — | EP | disclosed |