Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CPN1 | P15169 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22875265 | 0.92 | RIPK1 (0.35) | LMNAMAPK1ALDH1A1L3MBTL1GAA | |
| SCHEMBL22875260 | 0.91 | RIPK1 (0.39) | LMNAMAPK1ALDH1A1L3MBTL1GAA | |
| SCHEMBL7886867 | 0.80 | NAMPT (0.40) | ALDH1A1EPHX2KMT2AMEN1CPN1 | |
| SCHEMBL22875262 | 0.79 | GAA (0.39) | LMNAMAPK1ALDH1A1L3MBTL1GAA | |
| SCHEMBL22875422 | 0.77 | RIPK1 (0.38) | ALDH1A1L3MBTL1GAANPSR1CCR2 | |
| SCHEMBL26227988 | 0.77 | NAMPT (0.36) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22875336 | 0.77 | NAMPT (0.36) | ALDH1A1KMT2AMEN1SMN1; SMN2OPRL1 | |
| SCHEMBL14147222 | 0.76 | TLR9 (0.37) | ALDH1A1EPHX2KMT2AMEN1CPN1 | |
| SCHEMBL22875333 | 0.75 | GRM1 (0.36) | MAPK1ALDH1A1EPHX2KMT2AMEN1 | |
| SCHEMBL26227989 | 0.75 | GRM1 (0.36) | MAPK1ALDH1A1EPHX2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | LMNA 1840/4885MAPK1 3348/4885ALDH1A1 3363/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | LMNA 1482/4885MAPK1 3970/4885ALDH1A1 4009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.