Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22877015 | 0.77 | KDM4E (0.50) | HCAR3PDGFRBPDGFRAKMT2AMEN1 | |
| SCHEMBL18607516 | 0.76 | HCAR3 (0.47) | HCAR3PDGFRBPDGFRAKMT2AMEN1 | |
| SCHEMBL21016980 | 0.75 | CSF1R (0.39) | HCAR3HCRTR1ABL1HPGDS | |
| SCHEMBL21831103 | 0.74 | NOTUM (0.39) | KMT2AMEN1HCRTR1KDM4EL3MBTL1 | |
| SCHEMBL23768153 | 0.74 | HCAR3 (0.38) | HCAR3HCRTR1ABL1HRH4 | |
| SCHEMBL30842051 | 0.74 | KDM4E (0.48) | KDM4EGAACTSKHPGDSHDAC3 | |
| SCHEMBL22877248 | 0.71 | HCAR3 (0.44) | HCAR3PDGFRBPDGFRAKMT2AMEN1 | |
| SCHEMBL17031587 | 0.71 | HCAR3 (0.44) | HCAR3PDGFRBPDGFRAKMT2AMEN1 | |
| SCHEMBL17031679 | 0.71 | HCRTR1 (0.49) | HCAR3HCRTR1 | |
| SCHEMBL21016983 | 0.70 | HCRTR1 (0.33) | HCRTR1ABL1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107898-B1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICALS CO (JP) | 2021-01-06 | — | — | EP | disclosed |