Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.79 |
| ▸ | CDK4 | P11802 | 14/20 | 0.79 |
| ▸ | AURKA | O14965 | 5/20 | 0.69 |
| ▸ | CDK1 | P06493 | 4/20 | 0.69 |
| ▸ | CDK7 | P50613 | 4/20 | 0.69 |
| ▸ | CDK9 | P50750 | 4/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.69 |
| ▸ | PLK1 | P53350 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | CASP7 | P55210 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284091 | 0.88 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL12589637 | 0.83 | CDK2 (0.82) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL5620875 | 0.82 | CDK2 (0.76) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL29644961 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL2285895 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL6159771 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL6156572 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL6158661 | 0.81 | CDK2 (0.75) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL6159474 | 0.81 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL6158722 | 0.81 | CDK2 (0.75) | CDK2CDK4AURKACDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007500178-A | — | — | 2007-01-11 | — | — | JP | claimed |
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | CYCLACEL LIMITED (GB) | 2006-10-26 | — | — | US | claimed |
| EP-1648887-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | claimed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |
| US-20110195968-A1 | THIAZOLES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-08-11 | — | — | US | disclosed |
| US-20090030024-A1 | THIAZOLES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2009-01-29 | — | — | US | disclosed |
| CN-101309586-A | Thiazole compounds as fungicides | BAYER CROPSCIENCE AG (DE) | 2008-11-19 | — | — | CN | disclosed |
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | CYCLACEL LIMITED (GB) | 2006-10-26 | — | — | US | disclosed |
| EP-1648887-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030024-A1 | THIAZOLES AS FUNGICIDES | CYP4X1, CYP4Z1, RDX | CDK2 2065/4885CDK4 776/4885AURKA 2085/4885 |
| US-20110195968-A1 | THIAZOLES AS FUNGICIDES | CYP4X1, CYP4Z1, CYP3A4 | CDK2 2144/4885CDK4 818/4885AURKA 2015/4885 |
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | FRK, CNKSR1, TYK2 | CDK2 8/4885CDK4 76/4885AURKA 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.