Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.60 |
| ▸ | KRAS | P01116 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2288459 | 1.00 | TNFRSF1A (0.61) | TNFRSF1AABCG2KRASMAPTKMT2A | |
| SCHEMBL12375232 | 0.86 | MAPT (0.71) | ABCG2KRASMAPTKMT2AMEN1 | |
| SCHEMBL1938375 | 0.85 | MAPT (0.75) | ABCG2MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL30384473 | 0.85 | MAPT (0.75) | ABCG2MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL1938373 | 0.85 | MAPT (0.75) | ABCG2MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL30545313 | 0.85 | ABCG2 (0.82) | ABCG2KRASMAPTKMT2AMEN1 | |
| SCHEMBL12375238 | 0.83 | ABCG2 (0.64) | TNFRSF1AABCG2KRASMAPTKMT2A | |
| SCHEMBL19182764 | 0.77 | KRAS (0.71) | ABCG2KRASMAPTKMT2AMEN1 | |
| SCHEMBL19182765 | 0.77 | KRAS (0.71) | ABCG2KRASMAPTKMT2AMEN1 | |
| SCHEMBL10847648 | 0.75 | ABCG2 (1.00) | ABCG2MAPTKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | TERT, TYMS, NISCH | TNFRSF1A 3980/4885ABCG2 1032/4885KRAS 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.