Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eprodisate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | HBB | P68871 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eprodisate SCHEMBL2522165 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL2519328 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL4422542 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL293813 | 0.92 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL12979823 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL218553 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL218551 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| SCHEMBL2288142 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| Eprodisate SCHEMBL11909837 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GMNNLMNATP53 | |
| SCHEMBL2291877 | 0.89 | GMNN (0.55) | ALDH1A1SMN1; SMN2GMNNLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999009-B2 | Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-08-16 | — | — | US | claimed |
| US-20070244191-A1 | Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2007-10-18 | — | — | US | claimed |
| US-7999009-B2 | Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-08-16 | — | — | US | disclosed |
| US-20070244191-A1 | Strontium salts of sulphonic acids, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2007-10-18 | — | — | US | disclosed |