SCHEMBL2288948

SCHEMBL2288948

COc1cc(OC)nc(C(F)c2c(Cl)ccc(F)c2N)n1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 4/20 0.38
IDO1 P14902 1/20 0.35
MET P08581 8/20 0.34
INPPL1 O15357 4/20 0.32
SRC P12931 2/20 0.31
KDR P35968 2/20 0.31
KIT P10721 1/20 0.31
FGFR2 P21802 1/20 0.31
AXL P30530 1/20 0.31
FLT3 P36888 1/20 0.31
MST1R Q04912 1/20 0.31
ALK Q9UM73 2/20 0.31
FYN P06241 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2289577 0.90 TDO2 (0.33) TDO2IDO1
SCHEMBL2286162 0.89 TDO2 (0.38) TDO2IDO1METINPPL1FYN
SCHEMBL2286514 0.89 TDO2 (0.33) TDO2IDO1
SCHEMBL2288402 0.86 TDO2 (0.35) TDO2IDO1METINPPL1SRC
SCHEMBL2289018 0.85 TDO2 (0.35) TDO2IDO1METINPPL1SRC
SCHEMBL2285839 0.83 TDO2 (0.34) TDO2IDO1METINPPL1
SCHEMBL2287226 0.79 TDO2 (0.33) TDO2IDO1
SCHEMBL2287014 0.78 TDO2 (0.33) TDO2IDO1
SCHEMBL2291939 0.78 TDO2 (0.35) TDO2IDO1METINPPL1
SCHEMBL2285356 0.78 TDO2 (0.35) TDO2IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773124-B1 A USE OF SULFONANILIDES AS AGRICULTURAL AND HORTICULTURAL FUNGICIDE BAYER CROPSCIENCE AG (DE) 2012-08-22 EP disclosed
US-8008484-B2 Use of sulfonanilides as agricultural and horticultural fungicide BAYER CROPSCIENCE AG (DE) 2011-08-30 US disclosed
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide BAYER CROPSCIENCE AG (DE) 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide CBR3, CYP51A1, CBR1 TDO2 637/4885IDO1 559/4885MET 2186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.