Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890059 | 0.82 | LRRK2 (0.45) | LRRK2 | |
| SCHEMBL28180665 | 0.78 | AGXT (0.45) | HPGD | |
| SCHEMBL22890818 | 0.78 | LRRK2 (0.48) | LRRK2XDH | |
| SCHEMBL29644137 | 0.78 | LRRK2 (0.48) | LRRK2XDH | |
| SCHEMBL21045937 | 0.77 | TPMT (0.39) | HPGDGPR35 | |
| SCHEMBL29771512 | 0.76 | HSD17B10 (0.41) | IMPDH2HPGDGPR35 | |
| SCHEMBL22890254 | 0.76 | HSD17B10 (0.41) | IMPDH2HPGDGPR35 | |
| SCHEMBL22890472 | 0.74 | LRRK2 (0.48) | LRRK2XDH | |
| SCHEMBL22890422 | 0.74 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL31645961 | 0.73 | LRRK2 (0.43) | LRRK2HPGDGAAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |