Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644137 | 1.00 | LRRK2 (0.48) | LRRK2KMOHCAR2ARTDP1 | |
| SCHEMBL22890472 | 0.87 | LRRK2 (0.48) | LRRK2HCAR2S1PR2CSNK1A1CLK4 | |
| SCHEMBL22890059 | 0.84 | LRRK2 (0.45) | LRRK2 | |
| SCHEMBL22890466 | 0.83 | LRRK2 (0.51) | LRRK2S1PR2 | |
| SCHEMBL29643976 | 0.83 | LRRK2 (0.51) | LRRK2S1PR2 | |
| SCHEMBL22889708 | 0.78 | IMPDH2 (0.38) | LRRK2XDH | |
| SCHEMBL7672020 | 0.77 | HCAR2 (0.41) | KMOHCAR2TDP1MEN1KMT2A | |
| SCHEMBL22890422 | 0.76 | LRRK2 (0.48) | LRRK2AR | |
| SCHEMBL28222305 | 0.75 | HCAR2 (0.40) | KMOHCAR2TDP1MEN1KMT2A | |
| SCHEMBL20302398 | 0.74 | CSNK1A1 (0.41) | LRRK2ARTDP1CSNK1A1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |