Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.49 |
| ▸ | RELA | Q04206 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10057827 | 0.90 | SNCA (0.77) | SNCAMAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL26092946 | 0.86 | SNCA (0.76) | SNCACLK4CLK1CLK2DYRK1A | |
| SCHEMBL17279918 | 0.85 | SNCA (0.82) | SNCAMAPTSMN1; SMN2LMNANPC1 | |
| Emrusolmin SCHEMBL29376707 | 0.84 | SNCA (1.00) | SNCACLK4CLK1CLK2DYRK1A | |
| Emrusolmin SCHEMBL21440048 | 0.84 | SNCA (1.00) | SNCACLK4CLK1CLK2DYRK1A | |
| Emrusolmin SCHEMBL30597963 | 0.84 | SNCA (1.00) | SNCACLK4CLK1CLK2DYRK1A | |
| Emrusolmin SCHEMBL30547957 | 0.84 | SNCA (1.00) | SNCACLK4CLK1CLK2DYRK1A | |
| Emrusolmin SCHEMBL1660250 | 0.84 | SNCA (1.00) | SNCACLK4CLK1CLK2DYRK1A | |
| SCHEMBL23407836 | 0.84 | SNCA (0.69) | SNCACLK4CLK1CLK2DYRK1A | |
| SCHEMBL23407752 | 0.83 | SNCA (0.68) | SNCACLK4CLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307381-B1 | NEW DRUGS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES | UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) | 2021-01-13 | — | — | EP | disclosed |