Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.83 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.72 |
| ▸ | MMP2 | P08253 | 8/20 | 0.70 |
| ▸ | MMP13 | P45452 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19691535 | 1.00 | ADAMTS5 (0.83) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL19691526 | 0.93 | ADAMTS5 (0.77) | ADAMTS5ADAMTS4ADAM17MMP2 | |
| SCHEMBL19691638 | 0.91 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL19691551 | 0.91 | ADAMTS5 (0.74) | ADAMTS5ADAMTS4ADAM17MMP2 | |
| SCHEMBL19691552 | 0.91 | ADAMTS5 (0.74) | ADAMTS5ADAMTS4ADAM17MMP2 | |
| SCHEMBL19691622 | 0.89 | ADAMTS5 (0.91) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL19691611 | 0.89 | ADAMTS5 (0.83) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL19691545 | 0.87 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL21474467 | 0.87 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL19691553 | 0.86 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |