Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.69 |
| ▸ | MMP2 | P08253 | 4/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.69 |
| ▸ | ADAMTS4 | O75173 | 9/20 | 0.63 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19691579 | 0.84 | ADAMTS5 (0.68) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL19709398 | 0.84 | ADAMTS5 (0.68) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL20708349 | 0.83 | ADAMTS5 (0.64) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL20708471 | 0.83 | ADAMTS5 (0.64) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL22892253 | 0.83 | ADAMTS5 (0.75) | ADAMTS5ADAM17ADAMTS4ADAM10MMP12 | |
| SCHEMBL21582750 | 0.82 | ADAMTS5 (0.76) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL17871566 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL20708354 | 0.80 | ADAMTS5 (0.77) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 | |
| SCHEMBL19709325 | 0.78 | ADAMTS5 (0.64) | ADAMTS5MMP2ADAM17ADAMTS4 | |
| SCHEMBL19691583 | 0.77 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17ADAMTS4MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468955-B1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-01-06 | — | — | EP | disclosed |