Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20607115 | 0.84 | TTR (0.41) | TTRESR1MEN1KMT2ASLC6A2 | |
| SCHEMBL17732583 | 0.83 | TTR (0.44) | TTRESR1LMNASLC6A2SLC6A4 | |
| SCHEMBL10000323 | 0.75 | KDM4E (0.45) | ESR1MAPTMEN1LMNATP53 | |
| SCHEMBL9407170 | 0.75 | HSP90AA1 (0.55) | LMNASLC6A2SLC6A4SLC6A3CHRNA1 | |
| SCHEMBL28743655 | 0.74 | CHRNA1 (0.35) | MAPTLMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17300665 | 0.73 | TTR (0.41) | TTRESR1LMNASLC6A2SLC6A4 | |
| SCHEMBL20607132 | 0.73 | TTR (0.50) | TTRESR1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3595464 | 0.73 | ESR1 (0.59) | ESR1MAPTLMNAPKMSMN1; SMN2 | |
| SCHEMBL983707 | 0.73 | TTR (0.72) | TTRMAPTLMNATP53MAPK1 | |
| SCHEMBL2716447 | 0.73 | TTR (0.48) | TTRESR1LMNAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423440-B1 | 5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE FOR THE TREATMENT OF BRAIN TUMORS | OTSUKA PHARMA CO LTD (JP) | 2021-01-06 | — | — | EP | disclosed |