Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22894974 | 1.00 | NR1H2 (0.43) | NR1H2NR1H3GPR119AVPR2PDK2 | |
| SCHEMBL22894988 | 0.94 | NR1H2 (0.44) | NR1H2NR1H3GPR119AVPR2PDK2 | |
| SCHEMBL20077328 | 0.94 | NR1H2 (0.44) | NR1H2NR1H3GPR119AVPR2PDK2 | |
| SCHEMBL22894951 | 0.92 | NR1H2 (0.51) | NR1H2NR1H3GPR119AVPR2PDK2 | |
| SCHEMBL22894952 | 0.92 | NR1H2 (0.51) | NR1H2NR1H3GPR119AVPR2PDK2 | |
| SCHEMBL20077052 | 0.91 | NR1H2 (0.42) | NR1H2NR1H3GPR119SCN9A | |
| SCHEMBL20077090 | 0.90 | NR1H2 (0.42) | NR1H2NR1H3GPR119ITGB3ITGA2B | |
| SCHEMBL20077736 | 0.90 | NR1H2 (0.42) | NR1H2NR1H3GPR119ITGB3ITGA2B | |
| SCHEMBL22894954 | 0.89 | NR1H2 (0.41) | NR1H2NR1H3GPR119SCN9AKCNH2 | |
| SCHEMBL22894976 | 0.89 | NR1H2 (0.41) | NR1H2NR1H3GPR119ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10894775-B2 | Piperidine derivatives as liver X receptor beta agonists, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10894775-B2 | Piperidine derivatives as liver X receptor beta agonists, compositions, and their use | NR1H2, NR1H3, ADRB1 | NR1H2 1/4885NR1H3 2/4885GPR119 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.