Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 11/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22896895 | 0.90 | CAPN1 (0.51) | CTSSCAPN1 | |
| SCHEMBL22896458 | 0.88 | CAPN1 (0.45) | CTSSCAPN1 | |
| SCHEMBL22896785 | 0.86 | CAPN1 (0.39) | CTSSCAPN1 | |
| SCHEMBL22896419 | 0.85 | CAPN1 (0.39) | CTSSCAPN1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL22896541 | 0.85 | CAPN1 (0.45) | CTSSCAPN1 | |
| SCHEMBL22896890 | 0.85 | CAPN1 (0.41) | CTSSCAPN1 | |
| SCHEMBL22896708 | 0.85 | USP30 (0.44) | CAPN1USP30ALDH1A1 | |
| SCHEMBL22896850 | 0.85 | CAPN1 (0.42) | CTSSCAPN1 | |
| SCHEMBL22895950 | 0.85 | CAPN1 (0.42) | CTSSCAPN1 | |
| SCHEMBL22896365 | 0.85 | CAPN1 (0.43) | CTSSCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | HDAC6 40/4885HDAC1 517/4885CTSS 210/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | HDAC6 56/4885HDAC1 568/4885CTSS 199/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | HDAC6 40/4885HDAC1 517/4885CTSS 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.