Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.43 |
| ▸ | ITGAL | P20701 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.39 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22896969 | 0.87 | CAPN1 (0.42) | CAPN1 | |
| SCHEMBL22896435 | 0.85 | CAPN1 (0.44) | CAPN1 | |
| SCHEMBL22896052 | 0.85 | CAPN1 (0.42) | CAPN1 | |
| SCHEMBL22896891 | 0.84 | CAPN1 (0.44) | CAPN1 | |
| SCHEMBL22896974 | 0.84 | CAPN1 (0.48) | CAPN1 | |
| SCHEMBL21854095 | 0.84 | CAPN1 (0.54) | CAPN1 | |
| SCHEMBL22896644 | 0.84 | CAPN1 (0.43) | CAPN1 | |
| SCHEMBL22896870 | 0.83 | CAPN1 (0.48) | CAPN1 | |
| SCHEMBL22897050 | 0.83 | CAPN1 (0.40) | CAPN1 | |
| SCHEMBL22896037 | 0.83 | CAPN1 (0.40) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | ITGB2 3672/4885ICAM1 4477/4885ITGAL 4110/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | ITGB2 2933/4885ICAM1 4485/4885ITGAL 3478/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | ITGB2 3672/4885ICAM1 4477/4885ITGAL 4110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.