Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22897328 | 0.76 | DPP4 (1.00) | DPP4 | |
| SCHEMBL4502814 | 0.72 | CCR1 (0.65) | DPP4CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2159729 | 0.69 | CCR1 (0.67) | CCR1KCNH2 | |
| SCHEMBL2158845 | 0.67 | CCR1 (0.67) | DPP4CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5747070 | 0.67 | HPGD (0.61) | DPP4CYP2C19KMT2ANPC1RAB9A | |
| SCHEMBL2159492 | 0.67 | HPGD (0.61) | DPP4CYP2C19KMT2ANPC1RAB9A | |
| SCHEMBL8802537 | 0.66 | HPGD (0.59) | CYP2C19KMT2ANPC1RAB9AHPGD | |
| SCHEMBL22151090 | 0.66 | HPGD (0.59) | CYP2C19KMT2ANPC1RAB9AHPGD | |
| SCHEMBL5448808 | 0.65 | HPGD (0.70) | CYP2C19KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL7399516 | 0.65 | HPGD (0.66) | CYP2C19KMT2ANPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10894794-B1 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics | KING ABDULAZIZ UNIVERSITY (SA) | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10894794-B1 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics | DPP4, DPP3, DPP7 | DPP4 1/4885CYP2C19 1168/4885CYP1A2 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.