Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 13/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22898677 | 1.00 | ITGAL (0.39) | ITGALITGB2ICAM1ELANEAR | |
| SCHEMBL22898568 | 0.94 | ITGAL (0.42) | ITGALITGB2ICAM1ELANEAR | |
| SCHEMBL22898494 | 0.86 | ITGAL (0.40) | ITGALITGB2ICAM1ELANE | |
| SCHEMBL22898693 | 0.86 | ITGAL (0.40) | ITGALITGB2ICAM1ELANE | |
| SCHEMBL22898682 | 0.83 | ITGAL (0.36) | ITGALITGB2ICAM1ELANEAR | |
| SCHEMBL22898501 | 0.83 | ITGAL (0.36) | ITGALITGB2ICAM1ELANEAR | |
| SCHEMBL22898558 | 0.81 | ITGAL (0.41) | ITGALITGB2ICAM1ELANE | |
| SCHEMBL22898668 | 0.81 | PRCP (0.35) | — | |
| SCHEMBL22898575 | 0.81 | PRCP (0.35) | — | |
| SCHEMBL22898598 | 0.79 | ITGAL (0.44) | ITGALITGB2ICAM1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154941-B1 | SMALL MOLECULE LFA-1 INHIBITORS | ALLOCYTE PHARMACEUTICALS AG (CH) | 2021-01-20 | — | — | EP | disclosed |