Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 9/20 | 0.34 |
| ▸ | BRD4 | O60885 | 8/20 | 0.34 |
| ▸ | BRD2 | P25440 | 8/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 8/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900326 | 0.91 | BRD2 (0.40) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900324 | 0.90 | CREBBP (0.35) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900318 | 0.86 | QPCT (0.39) | CREBBPBRD4 | |
| SCHEMBL22900327 | 0.84 | BRD4 (0.34) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900431 | 0.79 | CREBBP (0.33) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900453 | 0.79 | BRD4 (0.36) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900459 | 0.78 | QPCT (0.40) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900398 | 0.78 | BRD4 (0.36) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900461 | 0.78 | BRD4 (0.34) | CREBBPBRD4BRD2BRD3MDM2 | |
| SCHEMBL22900438 | 0.78 | BRD4 (0.33) | CREBBPBRD4BRD2BRD3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |