Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 13/20 | 0.40 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | BRD2 | P25440 | 5/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900328 | 0.89 | BRD2 (0.44) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900316 | 0.84 | QPCT (0.53) | QPCT | |
| SCHEMBL22900325 | 0.81 | QPCT (0.40) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900416 | 0.78 | CREBBP (0.34) | BRD4BRD2BRD3CREBBPDYRK3 | |
| SCHEMBL22900460 | 0.74 | QPCT (0.40) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900454 | 0.74 | QPCT (0.41) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900430 | 0.74 | QPCT (0.41) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900399 | 0.73 | BRD4 (0.41) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900168 | 0.73 | QPCT (0.53) | QPCTBRD4BRD2BRD3CREBBP | |
| SCHEMBL22900166 | 0.72 | QPCT (0.51) | QPCTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |