SCHEMBL22901563

SCHEMBL22901563

COc1cnc(-c2ccc3cc(F)cc(OCc4cccc(OC)c4)c3n2)nc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.49
MAPT P10636 1/20 0.45
HTT P42858 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HTR1A P08908 3/20 0.43
DRD2 P14416 3/20 0.43
ABCB1 P08183 2/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.40
APP P05067 1/20 0.40
ALKBH1 Q13686 1/20 0.39
SLC2A1 P11166 1/20 0.39
SLC2A4 P14672 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22901574 0.94 MAOB (0.47) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901555 0.92 MAOB (0.50) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901551 0.91 MAPT (0.46) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901542 0.89 MAPT (0.47) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901577 0.89 MAOB (0.46) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901578 0.88 MAOB (0.48) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901550 0.88 SLC6A4 (0.47) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901562 0.88 MAPT (0.50) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901572 0.87 MEN1 (0.48) MAOBMAPTHTTSMN1; SMN2HTR1A
SCHEMBL22901561 0.85 MAOB (0.46) MAOBMAPTHTTSMN1; SMN2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021008588-A1 CLASS OF PYRIMIDINE QUINOLINE DERIVATIVES AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 广州新民培林医药科技有限公司 2021-01-21 WO disclosed