Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904525 | 0.75 | TDP2 (0.54) | LMNAPOLBHTTKMT2ABRD4 | |
| SCHEMBL22904284 | 0.75 | CHEK1 (0.43) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL22904283 | 0.72 | BRD4 (0.40) | NTRK1FGFR1NTRK2MAPTLMNA | |
| SCHEMBL22904113 | 0.72 | TDP2 (0.41) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL26135340 | 0.71 | TDP2 (0.37) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL30613656 | 0.71 | TDP2 (0.37) | CHEK1AURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL22904172 | 0.69 | NPC1 (0.44) | LMNAKMT2ABRD4TDP2CASP3 | |
| SCHEMBL22904431 | 0.69 | TDP2 (0.40) | MAPTLMNAPOLBHTTKMT2A | |
| SCHEMBL30613724 | 0.68 | TDP2 (0.38) | GSK3BCDK5TDP2 | |
| SCHEMBL26135520 | 0.68 | TDP2 (0.38) | GSK3BCDK5TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |