Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089552 | 0.84 | KDM4E (0.46) | TDP2KDM4ECASP3CASP7CASP9 | |
| SCHEMBL22904525 | 0.79 | TDP2 (0.54) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL9519108 | 0.78 | KDM4E (0.48) | KDM4ECASP3CASP7CASP6CASP8 | |
| SCHEMBL22904393 | 0.77 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904129 | 0.77 | AHR (0.54) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904128 | 0.77 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904252 | 0.77 | TDP2 (0.51) | TDP2KDM4ECASP3CASP7CASP9 | |
| SCHEMBL22904103 | 0.77 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904285 | 0.76 | TDP2 (0.50) | TDP2KDM4ECASP3CASP7CASP9 | |
| SCHEMBL22904369 | 0.75 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |