Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 19/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30780152 | 1.00 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL30099759 | 0.75 | CA12 (0.41) | — | |
| SCHEMBL25300707 | 0.75 | AHR (0.49) | TDP2CMA1AHR | |
| SCHEMBL6530104 | 0.72 | PDE3B (0.44) | TDP2CMA1AHR | |
| SCHEMBL23092822 | 0.72 | TDP2 (0.47) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL29861982 | 0.72 | TDP2 (0.47) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL30015036 | 0.71 | TDP2 (0.80) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904167 | 0.71 | TDP2 (0.80) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22885217 | 0.69 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL30699001 | 0.69 | TDP2 (0.51) | TDP2CASP3CASP7CASP9CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577546-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | Enliven Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044713-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044713-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |