Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904408 | 0.97 | DRD2 (0.42) | DRD2ADORA3DDB1CRBNCA12 | |
| SCHEMBL22904412 | 0.92 | DDB1 (0.42) | DRD2ADORA3DDB1CRBNCA12 | |
| SCHEMBL22904410 | 0.92 | DDB1 (0.42) | DRD2ADORA3DDB1CRBNCA12 | |
| SCHEMBL22904102 | 0.89 | DDB1 (0.43) | DRD2ADORA3DDB1CRBNCA1 | |
| SCHEMBL22904570 | 0.88 | DDB1 (0.43) | DRD2ADORA3DDB1CRBN | |
| SCHEMBL22904572 | 0.88 | DDB1 (0.43) | DRD2ADORA3DDB1CRBN | |
| SCHEMBL22904279 | 0.86 | DRD2 (0.42) | DRD2CA12CA1CA2CA9 | |
| SCHEMBL22904277 | 0.86 | DRD2 (0.42) | DRD2CA12CA1CA2CA9 | |
| SCHEMBL22904407 | 0.86 | DRD2 (0.42) | DRD2CA12CA1CA2CA9 | |
| SCHEMBL22904406 | 0.84 | DRD2 (0.43) | DRD2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |