Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904411 | 1.00 | DRD2 (0.41) | DRD2SIGMAR1MAPTATMCYP3A4 | |
| SCHEMBL22904098 | 1.00 | DRD2 (0.41) | DRD2SIGMAR1MAPTATMCYP3A4 | |
| SCHEMBL22904101 | 0.97 | DRD2 (0.42) | DRD2SIGMAR1MAPTCYP3A4FDFT1 | |
| SCHEMBL22904279 | 0.91 | DRD2 (0.42) | DRD2SIGMAR1CYP3A4NPSR1 | |
| SCHEMBL22904277 | 0.91 | DRD2 (0.42) | DRD2SIGMAR1CYP3A4NPSR1 | |
| SCHEMBL22904407 | 0.91 | DRD2 (0.42) | DRD2SIGMAR1CYP3A4NPSR1 | |
| SCHEMBL22904406 | 0.88 | DRD2 (0.43) | DRD2SIGMAR1MAPT | |
| SCHEMBL22904367 | 0.88 | BRD4 (0.45) | DRD2 | |
| SCHEMBL22904571 | 0.85 | DRD2 (0.46) | DRD2NPSR1 | |
| SCHEMBL22904569 | 0.85 | DRD2 (0.46) | DRD2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |