⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912690 | 0.92 | CNR2 (0.30) | — | |
| SCHEMBL21324926 | 0.82 | NPC1 (0.32) | — | |
| SCHEMBL22905254 | 0.82 | ELANE (0.30) | — | |
| SCHEMBL22857033 | 0.82 | — | — | |
| SCHEMBL21025014 | 0.80 | MTNR1A (0.32) | — | |
| SCHEMBL21690933 | 0.78 | — | — | |
| SCHEMBL9966007 | 0.72 | TLR8 (0.31) | — | |
| SCHEMBL21350817 | 0.71 | MAPT (0.39) | — | |
| SCHEMBL21472419 | 0.71 | MAPT (0.36) | — | |
| SCHEMBL21324882 | 0.69 | ELANE (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045960-A1 | SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-02-16 | — | — | US | disclosed |
| US-11530210-B2 | Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-12-20 | — | — | US | disclosed |
| US-20210017169-A1 | SUBSTITUTED HETEROAROMATIC PYRAZOLO-PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-21 | — | — | US | disclosed |