Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.69 |
| ▸ | NPC1 | O15118 | 11/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | GFER | P55789 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MIF | P14174 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | PKM | P14618 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387639 | 0.87 | RAB9A (0.64) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL4728826 | 0.83 | RAB9A (0.76) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL13325909 | 0.83 | RAB9A (0.83) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL2595462 | 0.82 | RAB9A (1.00) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL13325938 | 0.81 | RAB9A (0.80) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL13131131 | 0.81 | RAB9A (0.69) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL6390907 | 0.81 | RAB9A (0.69) | RAB9ANPC1KDM4EPOLBGFER | |
| Hydrochloric Acid SCHEMBL8874245 | 0.81 | RAB9A (0.97) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL29614084 | 0.81 | RAB9A (0.68) | RAB9ANPC1KDM4EPOLBGFER | |
| SCHEMBL13325743 | 0.81 | RAB9A (0.68) | RAB9ANPC1KDM4EPOLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | RAB9A 1429/4885NPC1 2550/4885KDM4E 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.