SCHEMBL22907154

SCHEMBL22907154

CC(O)Cc1ccc(-c2ccc3c4cnccc4n(C)c3c2)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
RAB9A P51151 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
ROCK2 O75116 3/20 0.35
ATM Q13315 1/20 0.34
ATR Q13535 1/20 0.34
GRIN1 Q05586 4/20 0.33
GRIN2B Q13224 4/20 0.33
MAPT P10636 2/20 0.33
PDE10A Q9Y233 1/20 0.33
MAOA P21397 4/20 0.33
MAOB P27338 4/20 0.33
ACHE P22303 1/20 0.33
METAP2 P50579 1/20 0.32
TOP2A P11388 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22906702 0.80 NPC1 (0.43) NPC1POLBGAARAB9ARXFP1
SCHEMBL20128566 0.79 NPC1 (0.43) NPC1POLBGAARAB9ARXFP1
SCHEMBL20128910 0.79 NPC1 (0.42) NPC1POLBGAARAB9ARXFP1
SCHEMBL29547590 0.78 MAPT (0.48) NPC1POLBGAARAB9ARXFP1
SCHEMBL14134198 0.78 MAPT (0.48) NPC1POLBGAARAB9ARXFP1
SCHEMBL20233573 0.78 NPC1 (0.39) NPC1POLBGAARAB9ARXFP1
SCHEMBL20128936 0.76 NPC1 (0.36) NPC1POLBGAARAB9ARXFP1
SCHEMBL20128557 0.75 CYP11B2 (0.47) MAOAMETAP2
SCHEMBL27097256 0.75 NPC1 (0.41) NPC1POLBGAARAB9ARXFP1
SCHEMBL20129125 0.74 ATM (0.39) NPC1POLBGAARAB9ARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021011913-A1 TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2021-01-21 WO disclosed