Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133403 | 0.84 | MAPT (0.50) | MAPTKIF11ACHEALOX5APFEN1 | |
| SCHEMBL20129027 | 0.81 | MAPT (0.40) | MAPTKIF11ACHE | |
| SCHEMBL20133146 | 0.81 | MAPT (0.53) | MAPTKIF11ACHE | |
| SCHEMBL20129026 | 0.80 | MAPT (0.39) | MAPTKIF11 | |
| SCHEMBL27099831 | 0.79 | MAPT (0.57) | MAPTKIF11ACHECHUK | |
| SCHEMBL27097263 | 0.78 | MAPT (0.55) | MAPTKIF11ACHECHUK | |
| SCHEMBL22906573 | 0.77 | MAPT (0.54) | MAPTKIF11ACHECHUK | |
| SCHEMBL20129077 | 0.75 | MAPT (0.45) | MAPTKIF11ACHE | |
| SCHEMBL20129079 | 0.72 | MAPT (0.42) | MAPTKIF11 | |
| SCHEMBL22906926 | 0.72 | KIF11 (0.68) | MAPTKIF11ACHECHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |