Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | GAA | P10253 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292639 | 0.90 | TRPA1 (0.37) | TRPA1MAPTGAATP53NOTUM | |
| SCHEMBL2290950 | 0.89 | MAPT (0.44) | MAPTGAATP53ALDH1A1NPSR1 | |
| SCHEMBL2289236 | 0.88 | TRPA1 (0.45) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2290726 | 0.88 | TRPA1 (0.39) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2292255 | 0.87 | GAA (0.49) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2290086 | 0.87 | GAA (0.43) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2295231 | 0.87 | GAA (0.38) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2293500 | 0.85 | GAA (0.47) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2289462 | 0.85 | GAA (0.47) | TRPA1MAPTGAATP53POLB | |
| SCHEMBL2287174 | 0.85 | GAA (0.44) | TRPA1MAPTGAATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258151-B2 | 3-aminoimidazo [1,2-A] pyridine derivatives as SGLT inhibitors | MERCK PATENT GMBH (DE) | 2012-09-04 | — | — | US | disclosed |
| US-20110195991-A1 | 3-AMINOIMIDAZO [1,2-A] PYRIDINE DERIVATIVES AS SGLT INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195991-A1 | 3-AMINOIMIDAZO [1,2-A] PYRIDINE DERIVATIVES AS SGLT INHIBITORS | GLP1R, SLC5A1, SLC5A2 | TRPA1 1229/4885MAPT 1138/4885GAA 1202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.