Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867042 | 0.83 | CRBN (0.40) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL21896543 | 0.82 | CRBN (0.46) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL22291343 | 0.82 | CRBN (0.57) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL24745374 | 0.79 | CRBN (0.43) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL24942108 | 0.79 | CRBN (0.63) | CRBNIKZF2 | |
| SCHEMBL24773134 | 0.79 | CRBN (0.44) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL25546133 | 0.79 | TNF (0.44) | BRD9ALDH1A1TDP1MAP1LC3B | |
| SCHEMBL22906862 | 0.78 | BRD9 (0.41) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL29547962 | 0.78 | BRD9 (0.41) | CRBNDDB1BRD9ALDH1A1CHRM2 | |
| SCHEMBL20372689 | 0.78 | CRBN (0.43) | CRBNDDB1BRD9ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |