Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19985146 | 1.00 | IDO1 (0.47) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL7252422 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL6137734 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL4763337 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL4761869 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL7927054 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL6642966 | 0.92 | IDO1 (0.45) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL23264408 | 0.84 | IDO1 (0.47) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL19696036 | 0.84 | IDO1 (0.47) | IDO1GSK3BALDH1A1BRPF1CREBBP | |
| SCHEMBL30839791 | 0.84 | IDO1 (0.47) | IDO1GSK3BALDH1A1BRPF1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3142665-B1 | MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION | APAXEN (BE) | 2021-01-20 | — | — | EP | disclosed |