Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763337 | 1.00 | IDO1 (0.45) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6137734 | 1.00 | IDO1 (0.45) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL6642966 | 0.96 | IDO1 (0.45) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL7252422 | 0.96 | IDO1 (0.45) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL7927054 | 0.96 | IDO1 (0.45) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL19985146 | 0.92 | IDO1 (0.47) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL22907690 | 0.92 | IDO1 (0.47) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL4241281 | 0.83 | IDO1 (0.41) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL4478604 | 0.83 | IDO1 (0.41) | IDO1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL13627349 | 0.83 | IDO1 (0.41) | IDO1MAPTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937684-A2 | TETRAHYDROQUINOLINES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | Wyeth a Corporation of the State of Delaware (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007047671-A2 | TETRAHYDROQUINOLINES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | WYETH (US) | 2007-04-26 | — | — | WO | disclosed |
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-04-19 | — | — | US | disclosed |
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-04-19 | — | — | US | disclosed |
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | WYETH (US) | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088022-A1 | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | HTR2C, HTR3B, HTR2A | IDO1 236/4885MAPT 3339/4885ALDH1A1 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.