⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567130 | 1.00 | — | — | |
| SCHEMBL22908297 | 0.96 | — | — | |
| SCHEMBL29694522 | 0.96 | — | — | |
| SCHEMBL22908302 | 0.96 | — | — | |
| SCHEMBL22908296 | 0.91 | — | — | |
| SCHEMBL22908303 | 0.91 | — | — | |
| SCHEMBL22908306 | 0.91 | — | — | |
| SCHEMBL22908329 | 0.89 | NLRP3 (0.72) | — | |
| SCHEMBL22908308 | 0.89 | NLRP3 (0.78) | — | |
| SCHEMBL22908295 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12221406-B2 | Compounds as NLRP3 inflammasome inhibitors and compositions and uses thereof | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2025-02-11 | — | — | US | disclosed |
| US-20220259144-A1 | COMPOUNDS AS NLRP3 INFLAMMASOME INHIBITORS AND COMPOSITIONS AND USES THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY | 2022-08-18 | — | — | US | disclosed |
| EP-3999045-A1 | COMPOUNDS AS NLRP3 INFLAMMASOME INHIBITORS AND COMPOSITIONS AND USES THEREOF | Virginia Commonwealth University (US) | 2022-05-25 | — | — | EP | disclosed |
| WO-2021011592-A1 | COMPOUNDS AS NLRP3 INFLAMMASOME INHIBITORS AND COMPOSITIONS AND USES THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-01-21 | — | — | WO | disclosed |