Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22908512 | 0.82 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22151085 | 0.82 | PLAU (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23642487 | 0.77 | CYP11B2 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12385894 | 0.77 | CYP11B2 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12385895 | 0.77 | CYP11B2 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22908473 | 0.76 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19129893 | 0.75 | DRD4 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18199156 | 0.75 | DRD4 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23642573 | 0.73 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22908507 | 0.73 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-24 | — | — | US | disclosed |
| EP-3672971-B1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INT (DE) | 2021-07-14 | — | — | EP | disclosed |
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BACE1, BACE2, APP | PSEN1 4/4885PSEN2 5/4885APH1B 8/4885 |
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BACE1, BACE2, APP | PSEN1 4/4885PSEN2 5/4885APH1B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.