Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29513312 | 0.84 | HSD17B10 (0.49) | STING1CDC7DBF4MAPK1LMNA | |
| SCHEMBL22908993 | 0.84 | HSD17B10 (0.49) | STING1CDC7DBF4MAPK1LMNA | |
| SCHEMBL22908903 | 0.75 | STING1 (0.47) | STING1MAPK1LMNAMCL1ERN1 | |
| SCHEMBL24771862 | 0.73 | STING1 (0.34) | STING1CDC7DBF4LMNAHSD17B10 | |
| SCHEMBL7848990 | 0.71 | KDM4E (0.52) | STING1IKBKBMAPK1HSD17B10KDM4E | |
| SCHEMBL29693859 | 0.69 | HSD17B10 (0.63) | STING1CDC7DBF4MAPK1LMNA | |
| SCHEMBL22905056 | 0.69 | HSD17B10 (0.63) | STING1CDC7DBF4MAPK1LMNA | |
| SCHEMBL22908882 | 0.67 | MCL1 (0.67) | STING1MAPK1LMNAMCL1HSD17B10 | |
| SCHEMBL22908953 | 0.67 | MCL1 (0.46) | STING1MAPK1MCL1EDNRA | |
| SCHEMBL23630822 | 0.67 | STING1 (1.00) | STING1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009365-A1 | BENZOTHIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES FOR THE MODULATION OF STING | CTXT PTY LIMITED (AU) | 2021-01-21 | — | — | WO | disclosed |