Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 5/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.37 |
| ▸ | CCNH | P51946 | 4/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | TGM2 | P21980 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28729284 | 0.94 | C1S (0.43) | MAPK14CCNKCDK12CDK7CCNH | |
| Trifluoroacetic Acid SCHEMBL28729286 | 0.94 | C1S (0.43) | MAPK14CCNKCDK12CDK7CCNH | |
| SCHEMBL28729837 | 0.86 | CDK7 (0.38) | MAPK14CCNKCDK12CDK7CCNH | |
| SCHEMBL24704356 | 0.86 | GRM4 (0.44) | MCHR1EGFRTGM2F13A1TGM1 | |
| SCHEMBL28729054 | 0.86 | GRM4 (0.44) | MCHR1EGFRTGM2F13A1TGM1 | |
| SCHEMBL29595455 | 0.86 | GRM4 (0.44) | MCHR1EGFRTGM2F13A1TGM1 | |
| SCHEMBL22911959 | 0.84 | TGM2 (0.47) | MAPK14CCNKCDK12LMNAPDGFRB | |
| SCHEMBL22912025 | 0.84 | CCNK (0.40) | MAT2ACCNKCDK12CDK7CCNH | |
| SCHEMBL24704572 | 0.81 | CCNK (0.43) | CCNKCDK12EGFR | |
| SCHEMBL29595528 | 0.81 | CCNK (0.43) | CCNKCDK12EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220388990-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2021011796-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. (US) | 2021-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220388990-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | CDK2, CCNK, CDK1 | MAT2A 2192/4885MAPK14 365/4885CCNK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.