Sugi Predict

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SCHEMBL2291253

SCHEMBL2291253

NC1CS(=O)(=O)CC1NC(=O)c1nc(-c2cnn3ccccc23)c(Cl)s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MARK3 P27448 1/20 0.41
▸ DGAT2 Q96PD7 1/20 0.40
▸ IGF1R P08069 9/20 0.36
▸ CYP3A4 P08684 3/20 0.36
▸ PIK3CB P42338 1/20 0.36
▸ SYK P43405 1/20 0.36
▸ CDK2 P24941 5/20 0.35
▸ KCNH2 Q12809 4/20 0.35
▸ CAMKK1 Q8N5S9 1/20 0.35
▸ CAMKK2 Q96RR4 1/20 0.35
▸ CCNT1 O60563 1/20 0.35
▸ CCNK O75909 1/20 0.35
▸ CCNE1 P24864 1/20 0.35
▸ CDK7 P50613 1/20 0.35
▸ CDK9 P50750 1/20 0.35
▸ CCNH P51946 1/20 0.35
▸ MNAT1 P51948 1/20 0.35
▸ CDK12 Q9NYV4 1/20 0.35
▸ EPHB3 P54753 2/20 0.34
▸ RIPK2 O43353 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2291250 0.91 MARK3 (0.41) MARK3IGF1RCYP3A4PIK3CBSYK
SCHEMBL2288445 0.90 DGAT2 (0.39) MARK3DGAT2IGF1RCYP3A4PIK3CB
SCHEMBL2291630 0.86 MARK3 (0.47) MARK3IGF1RCYP3A4SYKCDK2
SCHEMBL12418254 0.86 MARK3 (0.47) MARK3IGF1RSYKCDK2CAMKK1
SCHEMBL12418674 0.86 MARK3 (0.47) MARK3IGF1RSYKCDK2CAMKK1
SCHEMBL2292887 0.83 EPHB3 (0.37) MARK3IGF1RCYP3A4PIK3CBCDK2
SCHEMBL2296288 0.82 MARK3 (0.40) MARK3IGF1RCYP3A4PIK3CBSYK
SCHEMBL2296289 0.82 MARK3 (0.40) MARK3IGF1RCYP3A4PIK3CBSYK
SCHEMBL2292190 0.81 IRAK4 (0.41) MARK3CDK2CAMKK1CAMKK2CCNT1
SCHEMBL1849229 0.80 MAOB (0.47) MARK3CDK2CAMKK1CAMKK2CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US claimed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP claimed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US claimed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MARK3, MARK4, MARK1 MARK3 1/4885DGAT2 4573/4885IGF1R 2501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.