SCHEMBL22912949

SCHEMBL22912949

N#Cc1cccc(CN2CN(c3ccccc3)C3(CCN(C(=O)c4cnc(N)c(C=N)c4)CC3)C2=O)n1

nearest known ligand 0.72

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 20/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18374146 0.83 DDR1 (1.00) DDR1
SCHEMBL20187172 0.81 DDR1 (0.69) DDR1
SCHEMBL22912954 0.77 DDR1 (0.64) DDR1
SCHEMBL22913946 0.76 DDR1 (0.74) DDR1
SCHEMBL20187189 0.75 DDR1 (0.62) DDR1
SCHEMBL22914104 0.73 DDR1 (0.73) DDR1
SCHEMBL22914318 0.73 DDR1 (0.74) DDR1
SCHEMBL18374541 0.72 DDR1 (1.00) DDR1
SCHEMBL22914262 0.72 DDR1 (0.73) DDR1
SCHEMBL18374147 0.71 DDR1 (1.00) DDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3317279-B1 TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS HOFFMANN LA ROCHE (CH) 2021-01-27 EP disclosed