Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.49 |
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293610 | 1.00 | JAK1 (0.49) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2277845 | 1.00 | JAK1 (0.49) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2273150 | 0.96 | JAK1 (0.49) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2297227 | 0.88 | JAK1 (0.46) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2297921 | 0.88 | JAK1 (0.46) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2290091 | 0.88 | JAK1 (0.46) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2285755 | 0.88 | JAK1 (0.46) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL9959458 | 0.83 | JAK1 (0.47) | JAK1JAK2JAK3TYK2CCR5 | |
| SCHEMBL2275417 | 0.83 | JAK1 (0.48) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2274218 | 0.82 | JAK1 (0.49) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | JAK1 434/4885JAK2 122/4885JAK3 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.