Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 0.91 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.78 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.78 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.78 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.78 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.78 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050417 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050415 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050420 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21093513 | 0.95 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22915503 | 0.88 | APP (0.91) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050352 | 0.88 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050353 | 0.88 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21050354 | 0.88 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21093525 | 0.88 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19787609 | 0.84 | APP (0.91) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484884-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |