Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22915970 | 0.87 | POLB (0.55) | POLBNAMPTALDH1A1HPGDKDM4E | |
| SCHEMBL22915969 | 0.85 | HPGD (0.51) | POLBNAMPTHPGDKDM4EHTR2C | |
| SCHEMBL24062103 | 0.84 | HPGD (0.51) | POLBNAMPTHPGDKDM4ETSHR | |
| SCHEMBL22915968 | 0.83 | MAPK1 (0.60) | POLBNAMPTALDH1A1HPGDTP53 | |
| SCHEMBL22915886 | 0.83 | NAMPT (0.51) | POLBNAMPTALDH1A1HPGDKDM4E | |
| SCHEMBL24062095 | 0.82 | NAMPT (0.47) | POLBNAMPTALDH1A1HPGDKDM4E | |
| SCHEMBL22915948 | 0.82 | NAMPT (0.60) | NAMPTKDM4E | |
| SCHEMBL22915890 | 0.82 | KDM4E (0.47) | NAMPTHPGDKDM4EHTR2C | |
| SCHEMBL22915934 | 0.81 | HPGD (0.51) | POLBNAMPTALDH1A1HPGDGPR183 | |
| SCHEMBL22915936 | 0.81 | HPGD (0.53) | NAMPTALDH1A1HPGDTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548613-B1 | BACTERIAL GLUTAMINYL CYCLASE INHIBITORS AND USE THEREOF IN THE TREATMENT OF PERIODONTITIS | FRAUNHOFER GES FORSCHUNG (DE) | 2021-01-27 | — | — | EP | disclosed |