Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20214414 | 0.86 | SMN1; SMN2 (0.57) | HPGDCDK4CCND1GRM5GABRA1 | |
| SCHEMBL22915971 | 0.86 | SLC6A7 (0.52) | HPGDCDK4CCND1NAMPTHTR2C | |
| SCHEMBL20214653 | 0.86 | GRM5 (0.50) | HPGDGRM5NAMPTKDM4EL3MBTL1 | |
| SCHEMBL22916015 | 0.85 | POLB (0.57) | HPGDNAMPTHTR2CKDM4EHTT | |
| SCHEMBL22916012 | 0.85 | ALDH1A1 (0.53) | HPGDCDK4CCND1GRM5L3MBTL1 | |
| SCHEMBL22915970 | 0.85 | POLB (0.55) | HPGDCDK4CCND1GRM5GABRD | |
| SCHEMBL22915890 | 0.85 | KDM4E (0.47) | HPGDGRM5NAMPTHTR2CKDM4E | |
| SCHEMBL22915942 | 0.82 | GRM5 (0.50) | HPGDCDK4CCND1GRM5NAMPT | |
| SCHEMBL20214648 | 0.82 | KMT2A (0.47) | HPGDCDK4CCND1GRM5NAMPT | |
| SCHEMBL22915886 | 0.81 | NAMPT (0.51) | HPGDGRM5NAMPTHTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548613-B1 | BACTERIAL GLUTAMINYL CYCLASE INHIBITORS AND USE THEREOF IN THE TREATMENT OF PERIODONTITIS | FRAUNHOFER GES FORSCHUNG (DE) | 2021-01-27 | — | — | EP | disclosed |