Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 11/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | CA12 | O43570 | 3/20 | 0.74 |
| ▸ | CA2 | P00918 | 3/20 | 0.74 |
| ▸ | CA9 | Q16790 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | STS | P08842 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234944 | 0.90 | CA12 (0.89) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL26501496 | 0.90 | PANK3 (0.79) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL21423865 | 0.90 | PANK3 (0.79) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL31717258 | 0.88 | PANK3 (0.77) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL19748679 | 0.88 | PANK3 (1.00) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL19748656 | 0.87 | PANK3 (1.00) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL29178284 | 0.86 | CA12 (0.78) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL19748868 | 0.86 | PANK3 (1.00) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL19748641 | 0.86 | PANK3 (1.00) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 | |
| SCHEMBL26502461 | 0.85 | PANK3 (0.84) | PANK3SMN1; SMN2MAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210023081-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210023081-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | HMGCR, GCDH, CYP11A1 | PANK3 1573/4885SMN1; SMN2 1609/4885MAPT 1819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.