CYP11A1

Cholesterol side-chain cleavage enzyme, mitochondrial · P05108 · CYP11A1 on Sugi Atlas →

201 patent compounds predicted against CYP11A1, 137 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Aminoglutethimide (SCHEMBL4306)	1.00	1/20
Aminoglutethimide (SCHEMBL116988)	1.00	1/20
Aminoglutethimide (SCHEMBL1230613)	1.00	1/20
Aminoglutethimide (SCHEMBL7728932)	1.00	1/20
Aminoglutethimide (SCHEMBL28457203)	0.97	1/20
Aminoglutethimide (SCHEMBL28119771)	0.94	1/20
Aminoglutethimide (SCHEMBL28329350)	0.89	1/20
Aminoglutethimide (SCHEMBL11699322)	0.86	1/20
Aminoglutethimide (SCHEMBL28196944)	0.86	1/20
Aminoglutethimide (SCHEMBL27862969)	0.80	1/20
Aminoglutethimide (SCHEMBL159173)	0.78	1/20
Aminoglutethimide (SCHEMBL31287558)	0.76	1/20
SCHEMBL16509358	0.75	1/20
SCHEMBL13153484	0.74	1/20
Glutethimide (SCHEMBL113708)	0.72	1/20
Glutethimide (SCHEMBL113709)	0.72	1/20
SCHEMBL9634038	0.72	1/20
Glutethimide (SCHEMBL21119240)	0.72	1/20
Aminoglutethimide (SCHEMBL28273935)	0.71	1/20
SCHEMBL2907489	0.70	1/20

Clinical trials — most relevant to CYP11A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis	PHASE4	UNKNOWN
Testosterone Replacement in Older Men and Atherosclerosis Progression	PHASE4	COMPLETED
LDL Receptor Under Ezetimibe and Simvastatin	PHASE4	COMPLETED
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)	PHASE3	COMPLETED
Orteronel Maintenance Therapy in Patients With mCRPC Previously Treated With Novel Hormonal Agents	PHASE3	WITHDRAWN
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma	PHASE2	UNKNOWN
Study of Dose Escalation of Abiraterone Actetate in Prostate Cancer	PHASE2	COMPLETED
AMG 386 and Abiraterone for Advanced Prostate Cancer	PHASE2	COMPLETED
Smith-Lemli-Opitz Syndrome and Cholic Acid	PHASE1/PHASE2	COMPLETED
Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer	PHASE2	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy	PHASE1	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
Evaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary Syndrome	nan	UNKNOWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
LXR and Oocyte Meiosis Resumption	nan	UNKNOWN
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment	nan	UNKNOWN
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men	nan	UNKNOWN
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Furocyst - Poly Cystic Ovary Syndrome Study	nan	COMPLETED
Meal Timing on Glucose and Hyperandrogenism in PCOS Women	nan	UNKNOWN
Warfarin Effects on Male Fertility After Cardiac Surgery	nan	NOT_YET_RECRUITING
Study of Smith-Lemli-Opitz Syndrome	nan	COMPLETED
The Role of Insulin Resistance in PCOS	nan	UNKNOWN
Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)	nan	COMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.	nan	RECRUITING
Mechanisms of Glucose Lowering Effect of Colesevelam HCl	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CYP11A1 binder may also engage these)

Protein	Name	Similarity
P00189	—	1.000	P00189 →
P10612	—	1.000	P10612 →
O46515	—	0.995	O46515 →
Q9QZ82	—	0.995	Q9QZ82 →
Q2XV99	—	0.994	Q2XV99 →
P79202	—	0.993	P79202 →
P14137	—	0.993	P14137 →
P79153	—	0.992	P79153 →
Q92104	—	0.990	Q92104 →
Q9EPT4	—	0.990	Q9EPT4 →
P15393	—	0.989	P15393 →
P97720	—	0.986	P97720 →
Q9DBG1	—	0.986	Q9DBG1 →
P17177	—	0.984	P17177 →
P17178	—	0.984	P17178 →
Q64408	—	0.982	Q64408 →
Q28827	—	0.981	Q28827 →
Q07217	—	0.980	Q07217 →
CYP27A1	Sterol 26-hydroxylase, mitochondrial	0.980	landscape →
P30099	—	0.978	P30099 →
P15539	—	0.974	P15539 →
P30100	—	0.974	P30100 →
P46634	—	0.973	P46634 →
O88962	—	0.972	O88962 →
Q64658	—	0.971	Q64658 →
CYP8B1	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	0.971	landscape →
Q64505	—	0.971	Q64505 →
P15128	—	0.971	P15128 →
Q92045	—	0.970	Q92045 →
Q00557	—	0.969	Q00557 →