Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922565 | 0.88 | MAP4K1 (0.56) | MAP4K1DYRK1BMAP3K11TNIK | |
| SCHEMBL22922490 | 0.86 | MAP4K1 (0.58) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22922395 | 0.86 | MAP4K1 (0.61) | MAP4K1CYP11B2MAPK1EGLN1JAK2 | |
| SCHEMBL29869239 | 0.86 | MAP4K1 (0.61) | MAP4K1CYP11B2MAPK1EGLN1JAK2 | |
| SCHEMBL29869467 | 0.86 | MAP4K1 (0.61) | MAP4K1CYP11B2MAPK1EGLN1JAK2 | |
| SCHEMBL22922396 | 0.86 | MAP4K1 (0.61) | MAP4K1CYP11B2MAPK1EGLN1JAK2 | |
| SCHEMBL22858788 | 0.85 | MAP4K1 (0.66) | MAP4K1CYP11B2MAPK1EGLN1 | |
| SCHEMBL29608439 | 0.85 | MAP4K1 (0.66) | MAP4K1CYP11B2MAPK1EGLN1 | |
| SCHEMBL22858884 | 0.85 | MAP4K1 (0.66) | MAP4K1CYP11B2MAPK1EGLN1 | |
| SCHEMBL22922399 | 0.84 | MAP4K1 (0.57) | MAP4K1MAPK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |