Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29868940 | 0.87 | MAP4K1 (0.82) | MAP4K1PIK3CGTNIKMAP3K11 | |
| SCHEMBL22922379 | 0.87 | MAP4K1 (0.82) | MAP4K1PIK3CGTNIKMAP3K11 | |
| SCHEMBL29868818 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28501865 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29869046 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22922558 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22922477 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22922557 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22922478 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28501867 | 0.85 | MAP4K1 (1.00) | MAP4K1PIK3CGCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |