Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22923610 | 0.82 | PDE3A (0.35) | DRD3PDE3APDE4BPDE3B | |
| SCHEMBL22923576 | 0.80 | NAMPT (0.51) | — | |
| SCHEMBL22923624 | 0.79 | ITGB1 (0.37) | MEN1KMT2ATHRBKDM4EALDH1A1 | |
| SCHEMBL22923793 | 0.78 | MIF (0.34) | MEN1KMT2AMIFTHRBTDP1 | |
| SCHEMBL22923656 | 0.75 | TNF (0.43) | ALDH1A1TSHRPDE3APDE4BPDE3B | |
| SCHEMBL20159196 | 0.74 | PDE4B (0.43) | PDE3APDE4BPDE3B | |
| SCHEMBL20159108 | 0.74 | PDE4B (0.38) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL25095015 | 0.73 | PDE4B (0.37) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20138889 | 0.73 | PDE4B (0.41) | PDE3APDE4BPDE3B | |
| SCHEMBL20142921 | 0.72 | PDE4B (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013693-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-01-28 | — | — | WO | disclosed |